Iron-Catalyzed Csp2-Csp3 Cross-Coupling via Double Decarboxylation: One Step Synthesis of Remote Polar Alkenes.
Org Lett
; 26(10): 2029-2033, 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38437519
ABSTRACT
Herein, we report an efficient photoinduced iron-catalyzed strategy for cross-couplings of alkyl carboxylic and acrylic acids, which provides a powerful tool for the synthesis of a variety of alkenes with polar functional groups. This novel synthetic methodology can also be applied to the preparation of ketones by using α-keto acids. Mechanistic experiments revealed preliminary mechanistic details. Diverse functionalization could be achieved, which may help streamline the synthesis of complex analogues for drug discovery.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
/
Org. lett
/
Organic letters
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos