Harnessing antimicrobial peptides in endodontics.
Int Endod J
; 57(7): 815-840, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38441321
ABSTRACT
Endodontic therapy includes various procedures such as vital pulp therapy, root canal treatment and retreatment, surgical endodontic treatment and regenerative endodontic procedures. Disinfection and tissue repair are crucial for the success of these therapies, necessitating the development of therapeutics that can effectively target microbiota, eliminate biofilms, modulate inflammation and promote tissue repair. However, no current endodontic agents can achieve these goals. Antimicrobial peptides (AMPs), which are sequences of amino acids, have gained attention due to their unique advantages, including reduced susceptibility to drug resistance, broad-spectrum antibacterial properties and the ability to modulate the immune response of the organism effectively. This review systematically discusses the structure, mechanisms of action, novel designs and limitations of AMPs. Additionally, it highlights the efforts made by researchers to overcome peptide shortcomings and emphasizes the potential applications of AMPs in endodontic treatments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endodontia
/
Peptídeos Antimicrobianos
Limite:
Humans
Idioma:
En
Revista:
Int Endod J
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China