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A persistent prefrontal reference frame across time and task rules.
Muysers, Hannah; Chen, Hung-Ling; Hahn, Johannes; Folschweiller, Shani; Sigurdsson, Torfi; Sauer, Jonas-Frederic; Bartos, Marlene.
Afiliação
  • Muysers H; Institute for Physiology I, Medical Faculty, Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany.
  • Chen HL; Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany.
  • Hahn J; Institute for Physiology I, Medical Faculty, Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany.
  • Folschweiller S; Institute of Neurophysiology, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Sigurdsson T; Institute for Physiology I, Medical Faculty, Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany.
  • Sauer JF; Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany.
  • Bartos M; Sleep-Wake-Epilepsy Center and Center for Experimental Neurology, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nat Commun ; 15(1): 2115, 2024 Mar 08.
Article em En | MEDLINE | ID: mdl-38459033
ABSTRACT
Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or 'drifting' neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a 'core ensemble' of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Neurônios Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Neurônios Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido