Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation.
Genes Chromosomes Cancer
; 63(3): e23230, 2024 03.
Article
em En
| MEDLINE
| ID: mdl-38459940
ABSTRACT
Childhood melanoma is a rare and biologically heterogeneous pediatric malignancy. The differential diagnosis of pediatric melanoma is usually broad, including a wide variety of spindle cell or epithelioid neoplasms. Different molecular alterations affecting the MAPK and PI3K/AKT/mTOR pathways, tumor suppressor genes, and telomerase reactivation have been implicated in melanoma tumorigenesis and progression. Here, we report a novel MED15ATF1 fusion in a pediatric melanoma with spitzoid features and an aggressive clinical course.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Neoplasias Cutâneas
/
Proteínas de Fusão Oncogênica
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Nevo de Células Epitelioides e Fusiformes
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Glicina
/
Melanoma
Limite:
Child
/
Humans
Idioma:
En
Revista:
Genes Chromosomes Cancer
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos