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Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment.
Chutoprapat, Romchat; Witarat, Jatuporn; Jongpanyangarm, Panalee; Mang Sung Thluai, Lucy; Khankaew, Pichanon; Wah Chan, Lai.
Afiliação
  • Chutoprapat R; Cosmetic Science Program, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University Bangkok, 10330, Thailand. Electronic address: romchat.c@pharm.chula.ac.th.
  • Witarat J; Cosmetic Science Program, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University Bangkok, 10330, Thailand.
  • Jongpanyangarm P; Cosmetic Science Program, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University Bangkok, 10330, Thailand.
  • Mang Sung Thluai L; Cosmetic Science Program, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University Bangkok, 10330, Thailand.
  • Khankaew P; Cosmetic Science Program, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University Bangkok, 10330, Thailand.
  • Wah Chan L; Department of Pharmacy, National University of Singapore, Singapore. Electronic address: phaclw@nus.edu.sg.
Int J Pharm ; 654: 123980, 2024 Apr 10.
Article em En | MEDLINE | ID: mdl-38460769
ABSTRACT
Solid lipid microparticles (SLMs) represent a promising approach for drug delivery in anti-acne applications. In this study, asiatic acid-loaded SLMs (AASLMs) were prepared by melt emulsification method in conjunction with freeze-drying. Comprehensive evaluations comprised particle size, %entrapment efficiency (%EE), %labeled amount (%LA), surface morphology, stability, %release, %skin permeation, and anti-acne activity. The AASLMs exhibited an average particle size ranging from 7.46 to 38.86 µm, with %EE and %LA falling within the range of 31.56 to 100.00 and 90.43 to 95.38, respectively. The AASLMs demonstrated a spherical shape under scanning electron microscopy, and maintained stability over a 3-month period. Notably, formulations with 10 % and 15 % cetyl alcohol stabilized with poloxamer-188 (specifically F6 and F12) displayed a minimum inhibitory concentration (MIC) value of 75 mg/ml against Cutibacterium acnes. Furthermore, F12 exhibited a higher %release and %skin permeation compared to F6 over 24 h. In a single-blind clinical trial involving fifteen participants with mild-to-moderate acne, F12 showcased its potential not only in reducing porphyrin intensity and enhancing skin barriers but also in significantly improving skin hydration and brightness. However, further investigations with larger subject cohorts encompassing diverse age groups and genders are necessary to thoroughly establish the performance of the developed AASLMs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Acne Vulgar / Triterpenos Pentacíclicos Limite: Female / Humans / Male Idioma: En Revista: Int J Pharm Ano de publicação: 2024 Tipo de documento: Article País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Acne Vulgar / Triterpenos Pentacíclicos Limite: Female / Humans / Male Idioma: En Revista: Int J Pharm Ano de publicação: 2024 Tipo de documento: Article País de publicação: Holanda