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A novel lysosome-targeted fluorescent probe for precise formaldehyde detection in water samples, living cells and breast cancer tumors.
Wang, Haiping; Zhang, Yibin; Rong, Xiaoqian; Wang, Boling; Wang, Li; Wang, Chen; Gao, Wanxia; Ye, Xiansheng; Hou, Xiaoying; Liu, Wei; Wu, Meihui; Cheng, Yueting; Shu, Xiji; Shang, Jinting.
Afiliação
  • Wang H; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.
  • Zhang Y; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China; College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, China. Electronic address: zyb453@outlook.com.
  • Rong X; College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, China.
  • Wang B; College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, China.
  • Wang L; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.
  • Wang C; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
  • Gao W; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
  • Ye X; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.
  • Hou X; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.
  • Liu W; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
  • Wu M; College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, China.
  • Cheng Y; College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, China.
  • Shu X; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China. Electronic address: shangjinting@jhun.edu.cn.
  • Shang J; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China; Cancer Institute, School of Medicine, Jianghan University, Wuhan, China. Electronic address: xijishu@jhun.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc ; 313: 124105, 2024 May 15.
Article em En | MEDLINE | ID: mdl-38461560
ABSTRACT
This study investigated the potential ability of the fluorescent probe Ly-CHO to detect formaldehyde (FA) in living cells and tumor-bearing mice. Ly-CHO exhibited great selectivity, excellent sensitivity, and rapid response to FA, making it a valuable tool for tracking FA concentration changes. The probe was also found to target lysosomes specifically. Furthermore, Ly-CHO showed an obvious fluorescence increase in endogenous CHO detection after adding tetrahydrogen folic acid (THFA). This study validated Ly-CHO's possibility for FA imaging in vivo, with potential applications in understanding formaldehyde-related diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corantes Fluorescentes / Neoplasias Limite: Animals / Humans Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corantes Fluorescentes / Neoplasias Limite: Animals / Humans Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido