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CO2 cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid, and tau proteins.
Sur, Sandeepa; Lin, Zixuan; Li, Yang; Yasar, Sevil; Rosenberg, Paul B; Moghekar, Abhay; Hou, Xirui; Jiang, Dengrong; Kalyani, Rita R; Hazel, Kaisha; Pottanat, George; Xu, Cuimei; Pillai, Jay J; Liu, Peiying; Albert, Marilyn; Lu, Hanzhang.
Afiliação
  • Sur S; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Lin Z; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Li Y; Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Yasar S; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Rosenberg PB; Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Moghekar A; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Hou X; Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Jiang D; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Kalyani RR; Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Hazel K; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Pottanat G; Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Xu C; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Pillai JJ; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Liu P; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Albert M; Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Lu H; Division of Neuroradiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
J Cereb Blood Flow Metab ; : 271678X241240582, 2024 Mar 15.
Article em En | MEDLINE | ID: mdl-38489769
ABSTRACT
Vascular pathology is the second leading cause of cognitive impairment and represents a major contributing factor in mixed dementia. However, biomarkers for vascular cognitive impairment and dementia (VCID) are under-developed. Here we aimed to investigate the potential role of CO2 Cerebrovascular Reactivity (CVR) measured with phase-contrast quantitative flow MRI in cognitive impairment and dementia. Forty-five (69 ± 7 years) impaired (37 mild-cognitive-impairment and 8 mild-dementia by syndromic diagnosis) and 22 cognitively-healthy-control (HC) participants were recruited and scanned on a 3 T MRI. Biomarkers of AD pathology were measured in cerebrospinal fluid. We found that CBF-CVR was lower (p = 0.027) in the impaired (mean±SE, 3.70 ± 0.15%/mmHg) relative to HC (4.28 ± 0.21%/mmHg). After adjusting for AD pathological markers (Aß42/40, total tau, and Aß42/p-tau181), higher CBF-CVR was associated with better cognitive performance, including Montreal Cognitive Assessment, MoCA (p = 0.001), composite cognitive score (p = 0.047), and language (p = 0.004). Higher CBF-CVR was also associated with better physical function, including gait-speed (p = 0.006) and time for five chair-stands (p = 0.049). CBF-CVR was additionally related to the Clinical-Dementia-Rating, CDR, including global CDR (p = 0.026) and CDR Sum-of-Boxes (p = 0.015). CBF-CVR was inversely associated with hemoglobin A1C level (p = 0.017). In summary, CBF-CVR measured with phase-contrast MRI shows associations with cognitive performance, physical function, and disease-severity, independent of AD pathological markers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos