Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review.
Lancet Psychiatry
; 11(4): 285-294, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38490761
ABSTRACT
Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure (Hamilton Depression Rating Scale [HAMD]). Patients and clinicians matched each item within the 25 most frequently used measures with 80 previously identified domains of depression that matter to patients. Seven (9%) domains were not covered by the 25 most frequently used outcome measures (eg, mental pain and irritability). The HAMD covered a maximum of 47 (59%) of the 80 domains that matter to patients. An interim solution to facilitate evidence synthesis before a core outcome set is developed would be to use the most common measures and choose complementary scales to optimise domain coverage. TRANSLATIONS For the French and Dutch translations of the abstract see Supplementary Materials section.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Avaliação de Resultados em Cuidados de Saúde
Limite:
Humans
Idioma:
En
Revista:
Lancet Psychiatry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França