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Age-Related Features of the Response of Cancer Stem Cells and T Cells in Experimental Lung Cancer.
Pershina, O V; Ermakova, N N; Pakhomova, A V; Pan, E S; Sandrikina, L A; Zhukova, M A; Kogai, L V; Dygai, A M; Skurikhin, E G.
Afiliação
  • Pershina OV; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. ovpershina@gmail.com.
  • Ermakova NN; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Pakhomova AV; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Pan ES; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Sandrikina LA; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Zhukova MA; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Kogai LV; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Dygai AM; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Skurikhin EG; Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Bull Exp Biol Med ; 176(4): 486-490, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38492106
ABSTRACT
The responses of tumor stem cells and various populations of CD4 and CD8 T cells of young and aged C57BL/6 mice were studied in a lung cancer model. Using Lewis lung carcinoma cell line, an orthotopic model of lung cancer was modeled. Cancer stem cells, circulating tumor cells, and various populations of CD4 and CD8 T cells in the blood and lung tissue were studied by cytometry. We revealed age-related differences in the content of various populations of CD4 and CD8 T cells in the blood and lungs of intact young and aged mice. Age-related features of the reaction of various populations of cancer stem cells and CD4 and CD8 T cells in the blood and lungs of animals in the Lewis lung carcinoma were shown.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Lewis / Neoplasias Pulmonares Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Lewis / Neoplasias Pulmonares Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Estados Unidos