Melanoma extracellular vesicles inhibit tumor growth and metastasis by stimulating CD8 T cells.
Mol Immunol
; 169: 78-85, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38513590
ABSTRACT
Tumor cell-derived extracellular vesicles (EVs) play a crucial role in mediating immune responses by carrying and presenting tumor antigens. Here, we suggested that melanoma EVs triggered cytotoxic CD8 T cell-mediated inhibition of tumor growth and metastasis. Our results indicated that immunization of mice with melanoma EVs inhibited melanoma growth and metastasis while increasing CD8 T cells and serum interferon γ (IFN-γ) in vivo. In vitro experiments showed that melanoma EV stimulates dendritic cells (DCs) maturation, and mature dendritic cells induce T lymphocyte activation. Thus, tumor cell-derived EVs can generate anti-tumor immunity in a prophylactic setting and may be potential candidates for cell-free tumor vaccines.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vesículas Extracelulares
/
Melanoma
Limite:
Animals
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido