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PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules.
Matern, Benedict M; Niemann, Matthias.
Afiliação
  • Matern BM; Research and Development, PIRCHE AG, Berlin, Germany. Electronic address: ben.matern@pirche.com.
  • Niemann M; Research and Development, PIRCHE AG, Berlin, Germany.
Hum Immunol ; 85(3): 110789, 2024 May.
Article em En | MEDLINE | ID: mdl-38521663
ABSTRACT
PIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantation module, both versions yield identical results in 100% of the test population. In the solid organ module, 97% of the test population has identical PIRCHE scores. The deviating cases (3%) were attributed to refinements in the PIRCHE algorithm's specification. Furthermore, the magnitude of the difference is likely to be below the detection limit for clinical effects, confirming the equivalence in PIRCHE scores between versions 3.3 and 4.2.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Teste de Histocompatibilidade / Transplante de Órgãos / Epitopos de Linfócito T / Transplante de Células-Tronco / Doença Enxerto-Hospedeiro / Antígenos HLA Limite: Humans Idioma: En Revista: Hum Immunol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Teste de Histocompatibilidade / Transplante de Órgãos / Epitopos de Linfócito T / Transplante de Células-Tronco / Doença Enxerto-Hospedeiro / Antígenos HLA Limite: Humans Idioma: En Revista: Hum Immunol Ano de publicação: 2024 Tipo de documento: Article