Isolation of Diverse Simian Arteriviruses Causing Hemorrhagic Disease.
Emerg Infect Dis
; 30(4): 721-731, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38526136
ABSTRACT
Genetically diverse simian arteriviruses (simarteriviruses) naturally infect geographically and phylogenetically diverse monkeys, and cross-species transmission and emergence are of considerable concern. Characterization of most simarteriviruses beyond sequence analysis has not been possible because the viruses fail to propagate in the laboratory. We attempted to isolate 4 simarteriviruses, Kibale red colobus virus 1, Pebjah virus, simian hemorrhagic fever virus, and Southwest baboon virus 1, by inoculating an immortalized grivet cell line (known to replicate simian hemorrhagic fever virus), primary macaque cells, macrophages derived from macaque induced pluripotent stem cells, and mice engrafted with macaque CD34+-enriched hematopoietic stem cells. The combined effort resulted in successful virus isolation; however, no single approach was successful for all 4 simarteriviruses. We describe several approaches that might be used to isolate additional simarteriviruses for phenotypic characterization. Our results will expedite laboratory studies of simarteriviruses to elucidate virus-host interactions, assess zoonotic risk, and develop medical countermeasures.
Palavras-chave
Arteriviridae; KRCV-1; Kibale red colobus virus; NHP; PBJV; Pebjah virus; SHFV; SWBV; Simarterivirinae; United States; arterivirid; arterivirus; engraft; iPSC; induced pluripotent stem cell; nonhuman primate; simarterivirin; simarterivirus; simian hemorrhagic fever virus; southwest baboon virus; viruses; zoonoses
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arterivirus
Limite:
Animals
Idioma:
En
Revista:
Emerg Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos