Nanomedicine to aid immunogenic cell death (ICD)-based anticancer therapy.

Demuynck, Robin; Engelen, Yanou; Skirtach, André G; De Smedt, Stefaan C; Lentacker, Ine; Krysko, Dmitri V

Demuynck, Robin; Engelen, Yanou; Skirtach, André G; De Smedt, Stefaan C; Lentacker, Ine; Krysko, Dmitri V.

Afiliação

Demuynck R; Cell Death Investigation and Therapy Laboratory, Anatomy and Embryology Unit, Department of Human Structure and Repair, Ghent University, Faculty of Medicine and Health Sciences, 9000 Ghent, Belgium; Cancer Research Institute Ghent, 9000 Ghent, Belgium.
Engelen Y; Laboratory of General Biochemistry and Physical Pharmacy, Ghent Research Group on Nanomedicine, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.
Skirtach AG; Cancer Research Institute Ghent, 9000 Ghent, Belgium; NanoBioTechnology Laboratory, Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.
De Smedt SC; Laboratory of General Biochemistry and Physical Pharmacy, Ghent Research Group on Nanomedicine, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.
Lentacker I; Laboratory of General Biochemistry and Physical Pharmacy, Ghent Research Group on Nanomedicine, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.
Krysko DV; Cell Death Investigation and Therapy Laboratory, Anatomy and Embryology Unit, Department of Human Structure and Repair, Ghent University, Faculty of Medicine and Health Sciences, 9000 Ghent, Belgium; Cancer Research Institute Ghent, 9000 Ghent, Belgium. Electronic address: dmitri.krysko@ugent.be.

Trends Cancer ; 10(6): 486-489, 2024 Jun.

Article em En | MEDLINE | ID: mdl-38553361

ABSTRACT

ABSTRACT

Immunogenic cell death (ICD) is emerging as a key component of antitumor therapy that harnesses the immune system of the patient to combat cancer. In recent years, several efforts were made to improve the ICD-based therapies. Here, we discuss how nanomaterial-based strategies increase the efficacy of ICD and highlight their benefits and challenges.

Assuntos

Morte Celular Imunogênica; Nanomedicina; Neoplasias; Humanos; Morte Celular Imunogênica/efeitos dos fármacos; Neoplasias/imunologia; Neoplasias/terapia; Neoplasias/tratamento farmacológico; Neoplasias/patologia; Nanomedicina/métodos; Imunoterapia/métodos; Animais; Antineoplásicos/uso terapêutico; Antineoplásicos/farmacologia

Palavras-chave

DAMPs; anticancer immunity; apoptosis; necroptosis; pyroptosis and ferroptosis nanoparticles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanomedicina / Morte Celular Imunogênica / Neoplasias Limite: Animals / Humans Idioma: En Revista: Trends Cancer / Trends in cancer (Online) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bélgica País de publicação: Estados Unidos

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