Role of HLA-G in tumors and upon COVID-19 infection.
Hum Immunol
; 85(3): 110792, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38555250
ABSTRACT
HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target. In addition, it discusses urgent topics, which have to be addressed in HLA-G research.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
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Antígenos HLA-G
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SARS-CoV-2
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COVID-19
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2024
Tipo de documento:
Article