Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography.

Segan, Sandra; Krunic, Mihajlo J; Andric, Deana B; Sukalovic, Vladimir B; Penjisevic, Jelena Z; Jevtic, Ivana I

Segan, Sandra; Krunic, Mihajlo J; Andric, Deana B; Sukalovic, Vladimir B; Penjisevic, Jelena Z; Jevtic, Ivana I.

Afiliação

Segan S; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Republic of Serbia.
Krunic MJ; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Republic of Serbia.
Andric DB; Department of Organic Chemistry, Faculty of Chemistry, University of Belgrade, Belgrade, Republic of Serbia.
Sukalovic VB; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Republic of Serbia.
Penjisevic JZ; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Republic of Serbia.
Jevtic II; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Republic of Serbia.

Biomed Chromatogr ; 38(7): e5867, 2024 Jul.

Article em En | MEDLINE | ID: mdl-38558037

Assuntos

Inibidores da Colinesterase; Cromatografia de Fase Reversa; Donepezila; Interações Hidrofóbicas e Hidrofílicas; Piperidinas; Cromatografia em Camada Fina/métodos; Inibidores da Colinesterase/química; Inibidores da Colinesterase/farmacologia; Cromatografia de Fase Reversa/métodos; Donepezila/química; Donepezila/farmacologia; Piperidinas/química; Indanos/química; Barreira Hematoencefálica/metabolismo; Análise de Componente Principal

Palavras-chave

bloodbrain barrier permeability; donepezil; lipophilicity; principal component analysis; reversephased thinlayer chromatography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores da Colinesterase / Cromatografia de Fase Reversa / Interações Hidrofóbicas e Hidrofílicas / Donepezila Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido

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