Comparison of UVA vs UVB Photoaging Rat Models in Short-term Exposure.
Med Arch
; 78(2): 88-91, 2024.
Article
em En
| MEDLINE
| ID: mdl-38566862
ABSTRACT
Background:
Prolonged exposure to sunlight is known to induce photoaging of the skin, leading to various skin changes and disorders, such as dryness, wrinkles, irregular pigmentation, and even cancer. Ultraviolet A (UVA) and ultraviolet B (UVB) radiation are particularly responsible for causing photoaging.Objective:
This study aims to identify and compare photoaging rat models exposed to UVA and UVB.Methods:
This research method compared macroscopic (scoring degree of wrinkling) and microscopic (histology) signs and symptoms on skin samples of rat exposed to UVA and UVB for 4 weeks at a radiation dose of 840mJ/cm2.Results:
The results of this study indicated that the degree of wrinkling was highest in rat skin exposed to UVB rays by 51% (p<0.05). UVB histological results showed that the epidermis layer (40 µm, p<0.05) was thickened and the dermis layer (283 µm, p<0.05) was thinned in the skin of mice exposed to UVB light. The UVB group, showed the density of collagen in the dermis with a mean value of 55% (p<0.05).Conclusion:
Our results suggest that short-term exposure to UVB radiation (in the acute, subacute or subchronic phase) induces more rapid and pronounced damage to rat skin when compared to UVA radiation exposure.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento da Pele
Limite:
Animals
Idioma:
En
Revista:
Med Arch
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Indonésia
País de publicação:
Bósnia-Herzegóvina