Targeting fusion oncoproteins in childhood cancers: challenges and future opportunities for developing therapeutics.
J Natl Cancer Inst
; 116(7): 1012-1018, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38574391
ABSTRACT
Fusion oncoproteins are associated with childhood cancers and have proven challenging to target, aside from those that include kinases. As part of its efforts for targeting childhood cancers, the National Cancer Institute recently conducted a series on Novel Chemical Approaches for Targeting Fusion Oncoproteins. Key learnings on leading platforms and technologies that can be used to advance the development of molecular therapeutics that target fusion oncoproteins in childhood cancers are described. Recent breakthroughs in medicinal chemistry and chemical biology provide new ground and creative strategies to exploit for the development of targeted agents for improving outcomes against these recalcitrant cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Fusão Oncogênica
/
Terapia de Alvo Molecular
/
Neoplasias
Limite:
Child
/
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos