Slope between positive and negative ERG components in patients with open-angle glaucoma.
Doc Ophthalmol
; 149(1): 53-59, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38605262
ABSTRACT
PURPOSE:
To evaluate ERG morphology, in particular the slope between P50 and N95 components of the PERG, as well as between the b-wave and the photopic negative response (PhNR) of the light-adapted (LA) ERG in patients with retinal ganglion cell (RGC) dysfunction due to open-angle glaucoma.METHODS:
The PERG and LA-ERG traces of 16 glaucoma patients and 21 age-similar controls were retrospectively analysed. The ERG signal between the peak of the positive component (P50 and b-wave) towards the negative component (N95 and PhNR) was described by a linear regression y = a + bx, where the parameter b indicated the steepness of the P50-N95 and b-PhNR slope.RESULTS:
The P50-N95 slope was less steep in glaucoma patients (-0.079 ± 0.034 vs. -0.166 ± 0.050 in controls, p < 0.001), while the b-PhNR slope was not affected (-4.2 ± 2.1 vs. -4.4 ± 1.2, p = NS). The P50-N95 slope showed strong correlation with PhNR and N95 amplitude (r = -0.68 and -0.92, respectively; p < 0.001), while the b-PhNR slope correlated only with b-wave amplitude (r = -0.66, p < 0.001).CONCLUSIONS:
The P50-N95 slope is a sensitive indicator of RGC dysfunction in patients with open-angle glaucoma. A similar component of LA-ERG, the b-PhNR slope, is less affected by glaucomatous RGC dysfunction and probably originates from similar retinal mechanisms as the b-wave.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Ganglionares da Retina
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Campos Visuais
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Glaucoma de Ângulo Aberto
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Eletrorretinografia
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Pressão Intraocular
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Doc Ophthalmol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Eslovênia
País de publicação:
Holanda