Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging.
J Gerontol A Biol Sci Med Sci
; 79(7)2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38605684
ABSTRACT
BACKGROUND:
The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity.METHODS:
The Study of Muscle, Mobility and Aging (SOMMA) assessed ex vivo muscle mitochondrial energetics in 764 older adults (mean ageâ =â 76.4, 56.5% women, and 85.9% non-Hispanic White) by high-resolution respirometry of permeabilized muscle fibers. We estimated the proportional odds ratio (POR [95% CI]) for the likelihood of greater multimorbidity (4 levels 0 conditions, Nâ =â 332; 1 condition, Nâ =â 299; 2 conditions, Nâ =â 98; or 3+ conditions, Nâ =â 35) from an index of 11 conditions, per SD decrement in muscle mitochondrial energetic parameters. Distribution of conditions allowed for testing the associations of maximal muscle energetics with some individual conditions.RESULTS:
Lower oxidative phosphorylation supported by fatty acids and/or complex I- and II-linked carbohydrates (eg, Max OXPHOSCI+CII) was associated with a greater multimorbidity index score (PORâ =â 1.32 [1.13, 1.54]) and separately with diabetes mellitus (ORâ =â 1.62 [1.26, 2.09]), depressive symptoms (ORâ =â 1.45 [1.04, 2.00]) and possibly chronic kidney disease (ORâ =â 1.57 [0.98, 2.52]) but not significantly with other conditions (eg, cardiac arrhythmia, chronic obstructive pulmonary disease).CONCLUSIONS:
Lower muscle mitochondrial bioenergetic capacities were associated with a worse composite multimorbidity index score. Our results suggest that decrements in muscle mitochondrial energetics may contribute to a greater global burden of disease and are more strongly related to some conditions than others.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Metabolismo Energético
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Multimorbidade
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Mitocôndrias Musculares
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
J Gerontol A Biol Sci Med Sci
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J. gerontol. Ser. A, Biol. sci. med. sci
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Journals of gerontology. Series A, Biological sciences and medical sciences
Assunto da revista:
GERIATRIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos