Altered cerebral white matter network topology and cognition in children with obstructive sleep apnea.
Sleep Med
; 118: 63-70, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38613858
ABSTRACT
OBJECTIVES:
The study aimed to explore the underlying mechanisms of OSA-related cognitive impairment by investigating the altered topology of brain white matter networks in children with OSA.METHODS:
Graph theory was used to examine white matter networks' network topological properties in 46 OSA and 31 non-OSA children. All participants underwent MRI, polysomnography, and cognitive testing. The effects of the obstructive apnea-hypopnea index (OAHI) on topological properties of white matter networks and network properties on cognition were studied using hierarchical linear regression. Mediation analyses were used to explore whether white matter network properties mediated the effects of OAHI on cognition.RESULTS:
Children with OSA had significantly higher assortativity than non-OSA children. Furthermore, OAHI was associated with the nodal properties of several brain regions, primarily in the frontal and temporal lobes. The relationship between OAHI and verbal comprehension index was mediated through clustering coefficients in the right temporal pole of the superior temporal gyrus.CONCLUSIONS:
OSA affects the development of white matter networks in children's brains. Besides, the mediating role of white matter network properties between the OAHI and the verbal comprehension index provided neuroimaging evidence of impaired cognitive function in children with OSA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Polissonografia
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Apneia Obstrutiva do Sono
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Substância Branca
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Sleep Med
Assunto da revista:
NEUROLOGIA
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PSICOFISIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article