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Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34.
He, Xingzhi; Li, Wenwen; Ma, Huan.
Afiliação
  • He X; Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China.
  • Li W; Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China.
  • Ma H; Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China; Research Units for Emotion
Trends Neurosci ; 47(5): 319-321, 2024 May.
Article em En | MEDLINE | ID: mdl-38614892
ABSTRACT
In a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / Proteína Fosfatase 1 / Plasticidade Neuronal / Neurônios Limite: Animals / Humans Idioma: En Revista: Trends Neurosci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / Proteína Fosfatase 1 / Plasticidade Neuronal / Neurônios Limite: Animals / Humans Idioma: En Revista: Trends Neurosci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido