Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine.
Pharmacol Res
; 203: 107179, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38615876
ABSTRACT
Exosomes, small yet vital extracellular vesicles, play an integral role in intercellular communication. They transport critical components, such as proteins, lipid bilayers, DNA, RNA, and glycans, to target cells. These vesicles are crucial in modulating the extracellular matrix and orchestrating signal transduction processes. In oncology, exosomes are pivotal in tumor growth, metastasis, drug resistance, and immune modulation within the tumor microenvironment. Exosomal proteins, noted for their stability and specificity, have garnered widespread attention. This review delves into the mechanisms of exosomal protein loading and their impact on tumor development, with a focus on the regulatory effects of natural products and traditional Chinese medicine on exosomal protein loading and function. These insights not only offer new strategies and methodologies for cancer treatment but also provide scientific bases and directions for future clinical applications.
Palavras-chave
Astragalus polysaccharides (PubChem CID: 13943297); Atractylenolide I (PubChem CID: 5321018); Berberine (PubChem CID: 2353); Chemotherapeutic resistance; Deoxyelephantopin (PubChem CID: 6325056); Epigallocatechin gallate (PubChem CID: 65064); Exosomal proteins; Gallic acid (PubChem CID: 370); Immune evasion; Kaempferitrin (PubChem CID: 5486199); Manumycin A (PubChem CID: 6438330); Natural products; Salidroside (PubChem CID: 159278); Shikonin (PubChem CID: 479503); Traditional Chinese medicine; Tumor microenvironment
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Exossomos
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Medicina Tradicional Chinesa
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Holanda