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Lectins As Effective Tools in the Study of the Biliary Network and the Parenchymal Architecture of the Zebrafish (Danio rerio) Liver.
Bhavsar, Hayden; Robinson, Zoe; Benson, Matthew; Getachew, Feven; González-Rosa, Juan Manuel; Lafontant, Pascal J.
Afiliação
  • Bhavsar H; Biology Department, Grinnell College, Grinnell, Iowa, USA.
  • Robinson Z; Biology Department, Grinnell College, Grinnell, Iowa, USA.
  • Benson M; Biology Department, Grinnell College, Grinnell, Iowa, USA.
  • Getachew F; Biology Department, Grinnell College, Grinnell, Iowa, USA.
  • González-Rosa JM; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Lafontant PJ; Biology Department, Grinnell College, Grinnell, Iowa, USA.
Zebrafish ; 21(2): 177-180, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38621207
ABSTRACT
Lectins are carbohydrate-binding proteins with specific affinity to glycoconjugates expressed in various tissues. Lectins are of substantial utility as research, histochemical, and diagnostic tools in mammalian systems. Reactivity of 12 commonly used plant-based lectins was studied in zebrafish liver. Four lectins, tomato lectin (TL), wheat germ agglutinin, concanavalin A, and Jacalin showed strong reactivity to hepatic parenchymal structures. Importantly, TL reacted to glycoconjugates within segments of the larval and adult intrahepatic biliary network, from canaliculi to bile ducts. We provide evidence that lectins can serve as important histochemical tools to investigate the structural and functional characteristics of the zebrafish liver.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Lectinas Limite: Animals Idioma: En Revista: Zebrafish Assunto da revista: BIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Lectinas Limite: Animals Idioma: En Revista: Zebrafish Assunto da revista: BIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
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