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Monoclonal proliferation of B-cells with two integration sites of bovine leukemia virus proviral DNA in cattle with enzootic bovine leukosis.
Maezawa, Masaki; Takezawa, Shiho; Sakaguchi-Maezawa, Kana; Tanaka, Yusuke; Watanabe, Ken-Ichi; Kobayashi, Yoshiyasu; Inokuma, Hisashi.
Afiliação
  • Maezawa M; Laboratory of OSG Veterinary Science for Global Disease Management, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
  • Takezawa S; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
  • Sakaguchi-Maezawa K; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
  • Tanaka Y; Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Hokkaido, Japan.
  • Watanabe KI; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
  • Kobayashi Y; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
  • Inokuma H; Laboratory of OSG Veterinary Science for Global Disease Management, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
J Vet Med Sci ; 86(6): 653-655, 2024 Jun 01.
Article em En | MEDLINE | ID: mdl-38631888
ABSTRACT
The present study analyzed B-cell clonality and bovine leukemia virus (BLV) provirus integration sites in cattle with enzootic bovine leukosis (EBL) having BLV proviral copy numbers less or greater than the number of bovine nucleated cells. EBL cattle with BLV copy numbers less than the number of bovine nucleated cells showed monoclonal and biclonal proliferation of B-cells with one BLV provirus integration site. On the other hand, EBL cattle with BLV copy numbers greater than the number of bovine nucleated cells showed monoclonal proliferation of B-cells with two BLV provirus integration sites. These results suggest that superinfection of BLV can occur in EBL cattle.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Viral / Linfócitos B / Provírus / Leucose Enzoótica Bovina / Vírus da Leucemia Bovina Limite: Animals Idioma: En Revista: J Vet Med Sci Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Viral / Linfócitos B / Provírus / Leucose Enzoótica Bovina / Vírus da Leucemia Bovina Limite: Animals Idioma: En Revista: J Vet Med Sci Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão