Individualized homeopathic medicines in preventing the progression from pre-diabetes to diabetes: A double-blind, randomized, placebo-controlled, parallel-arm trial.
Explore (NY)
; 20(5): 102995, 2024.
Article
em En
| MEDLINE
| ID: mdl-38631987
ABSTRACT
CONTEXT Pre-diabetes is a significant public health problem worldwide. India has a very high rate of progression from pre-diabetes to diabetes, 75-78 per thousand persons per year. OBJECTIVE:
To study the efficacy of individualized homeopathic medicinal products (HMPs) against placebos in preventing the progression from pre-diabetes to diabetes.DESIGN:
Six-month, double-blind, randomized (11), two parallel arms, placebo-controlled trial.SETTING:
Outpatient departments of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal, India. PATIENTS Sixty participants with pre-diabetes.INTERVENTIONS:
Verum HMPs plus yoga therapy (YT; n = 30); control identical-looking placebos plus YT (n = 30). MAIN OUTCOMEMEASURES:
The primary efficacy endpoint was the proportion of participants progressing from pre-diabetes to diabetes, measured after three and six months. Secondary outcomes comprised of fasting blood glucose (FBS), oral glucose tolerance test (OGTT), glycated hemoglobin percentage (HbA1c%), lipid profile, liver enzymes (alanine transaminase, aspartate transaminase), urea and creatinine, and Measure Yourself Medical Outcome Profile version 2 (MYMOP-2); all measured after 3 and 6 months.RESULTS:
The proportion of participants converted from pre-diabetics to diabetics (n/N; n = diabetics, N = prediabetics) was significantly less in the verum group than control HbA1C% (month 3 verum - 2/30 versus control - 11/30, p = 0.003; month 6 3/30 vs. 2/30, p = 0.008), OGTT (month 3 0/30 vs. 8/30, p = 0.015; month 6 0/30 vs. 1/30, p = 0.008), but not according to FBS (month 3 1/30 vs. 1/30, p = 0.779; month 6 1/30 vs. 3/30, p = 0.469). Several secondary outcomes also revealed significant improvements in the verum group than in placebo HbA1C% (p < 0.001), OGTT (p = 0.001), serum ALT (p = 0.031), creatinine (p = 0.012), and MYMOP-2 profile scores (p < 0.001). Sulphur, Bryonia alba, and Thuja occidentalis were the most frequently indicated medicines. Thus, HMPs outperformed placebos by successfully preventing the progression of pre-diabetes to diabetes. TRIAL REGISTRATION Clinical Trials Registry - India CTRI/2022/04/042,026; UTN U1111-1277-0021.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
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Glicemia
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Hemoglobinas Glicadas
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Materia Medica
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Progressão da Doença
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Explore (NY)
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos