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Chloroperfluoropolyether carboxylate compounds: A review.
Bucaletti, Elisabetta; Barola, Carolina; Galarini, Roberta.
Afiliação
  • Bucaletti E; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via G. Salvemini, 1, 06126, Perugia, Italy.
  • Barola C; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via G. Salvemini, 1, 06126, Perugia, Italy.
  • Galarini R; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via G. Salvemini, 1, 06126, Perugia, Italy. Electronic address: r.galarini@izsum.it.
Chemosphere ; 357: 142045, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38641293
ABSTRACT
Several new per- and polyfluoroalkyl substances (PFASs) have been synthesized to replace traditional (legacy) PFASs frequently without clear information on their structure, use and potential toxicity. Among them, chloroperfluoropolyether carboxylates (ClPFPECAs) are an emerging group used as processing aids in the production of fluoropolymers to replace the ammonium salt of perfluorononanoic acid (PFNA). The Solvay Company has produced ClPFPECAs as a mixture of six congeners (oligomers) since the mid-1990s, but other possible manufacturers and annual quantities synthesized and used worldwide are unknown. Initial studies to monitor their presence were conducted because of public authority concerns about suspect environmental contamination near fluoropolymer plants. As of 2015, these chemicals have been found in soil, water, vegetative tissues and wildlife, as well as in biological fluids of exposed workers and people, in research carried out mainly in the United States (New Jersey) and Italy. Analysis of wildlife collected even in non-industrialized areas demonstrated widespread occurrence of ClPFPECAs. From the analytical point of view, the (presumptive) evidence of their presence was obtained through the application of non-targeted approaches performed by liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). Available toxicological data show that ClPFPECAs have similar adverse effects than the compounds which they have replaced, whereas their carcinogenic potential and reproductive damage are currently unknown. All these observations once again cast doubt on whether many alternatives to traditional PFAS are actually safer for the environment and health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Carboxílicos / Poluentes Ambientais Limite: Animals / Humans Idioma: En Revista: Chemosphere Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Carboxílicos / Poluentes Ambientais Limite: Animals / Humans Idioma: En Revista: Chemosphere Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália País de publicação: Reino Unido