Meningeal Lymphatics in Central Nervous System Diseases.
Annu Rev Neurosci
; 47(1): 323-344, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38648267
ABSTRACT
Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment, including brain tumors, inflammatory diseases such as multiple sclerosis, CNS injuries, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review, we discuss recent evidence of the contribution of meningeal lymphatics to neurological diseases, as well as the available experimental methods for manipulating meningeal lymphatics in these conditions. Finally, we also provide a discussion of the pressing questions and challenges in utilizing meningeal lymphatics as a prime target for CNS therapeutic intervention and possibly drug delivery for brain disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Central
/
Meninges
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos