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Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder.
Zuluaga, Paola; Fuster, Daniel; Blanes, Rafael; Hernández-Rubio, Anna; Miquel, Laia; Torrens, Marta; Rubio, Gabriel; Bolao, Ferrán; Liangpunsakul, Suthat; Abellí-Deulofeu, Enric; Rodriguez de Fonseca, Fernando; Muga, Robert.
Afiliação
  • Zuluaga P; Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, IGTP, Badalona, Spain.
  • Fuster D; Universitat Autònoma de Barcelona, Bellaterra, Spain.
  • Blanes R; Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, IGTP, Badalona, Spain.
  • Hernández-Rubio A; Universitat Autònoma de Barcelona, Bellaterra, Spain.
  • Miquel L; Alcohol Unit, Hospital Universitari Son Espases, IdISPa, Palma de Mallorca, Spain.
  • Torrens M; Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, IGTP, Badalona, Spain.
  • Rubio G; Universitat Autònoma de Barcelona, Bellaterra, Spain.
  • Bolao F; Alcohol Unit, Department of Psychiatry, Hospital Clínic, IDIBAPS, Barcelona, Spain.
  • Liangpunsakul S; Universitat de Barcelona, Barcelona, Spain.
  • Abellí-Deulofeu E; Universitat Autònoma de Barcelona, Bellaterra, Spain.
  • Rodriguez de Fonseca F; Department of Neuropsychiatry and Addictions, Hospital del Mar, IMIM, Barcelona, Spain.
  • Muga R; Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain.
Alcohol Clin Exp Res (Hoboken) ; 48(7): 1313-1321, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38720158
ABSTRACT

BACKGROUND:

Effective screening for alcohol-associated liver disease is relevant in the context of chronic, excessive alcohol consumption. Patients with alcohol-associated liver disease are often not diagnosed until their liver disease is decompensated. We analyzed the prevalence and associations of Fibrosis-4 index (FIB-4) values suggestive of advanced liver fibrosis in patients referred for their first treatment of alcohol use disorder (AUD).

METHODS:

We conducted a cross-sectional, multicenter study of noncirrhotic individuals referred for their first AUD treatment between March 2013 and April 2021. We obtained sociodemographic data, substance use characteristics, and blood samples at admission. We considered a FIB-4 value ≥2.67 suggestive of advanced liver fibrosis and used logistic regression analyses to identify features associated with this value.

RESULTS:

We included 604 patients (67% male), with a median age at admission of 48 years [IQR 41-56 years]. The median duration of regular alcohol consumption was 21 years [IQR 18-30 years] and the median alcohol consumption was 105 standard drink units (SDU)/week [IQR 63-160 SDU/week]. A FIB-4 value ≥ 2.67 was present in 19.3% of cases. These patients reported more frequent binge drinking (75.4% vs. 66%, p = 0.05) than those with FIB-4 values below 2.67. In multivariate analysis, a history of binge drinking (OR 1.9, 95% CI, 1.05-3.47), anemia (OR 2.95, 95% CI, 1.42-6.11), leukopenia (OR 7.46, 95% CI, 2.07-26.8), and total serum bilirubin >1 mg/dL (OR 6.46, 95% CI, 3.57-11.7) were independently associated with FIB-4 values ≥2.67.

CONCLUSIONS:

One in five patients admitted to treatment for AUD without evidence of decompensated liver disease have FIB-4 values suggestive of advanced liver fibrosis. The presence of a binge drinking history, anemia, leukopenia, and elevated bilirubin levels is associated with high FIB-4 values.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Alcohol Clin Exp Res (Hoboken) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Alcohol Clin Exp Res (Hoboken) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Estados Unidos