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Significant Mitral Regurgitation After Permanent Right Ventricular Pacemaker Implantation: Prognostic Implications.
Nabeta, Takeru; Galloo, Xavier; Tops, Laurens; Stassen, Jan; Marsan, Nina Ajmone; van der Bijl, Pieter; Bax, Jeroen J.
Afiliação
  • Nabeta T; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: takerunabeta@gmail.com.
  • Galloo X; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Tops L; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Stassen J; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Jessa Hospital, Hasselt, Belgium.
  • Marsan NA; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • van der Bijl P; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Bax JJ; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Heart Centre, University of Turku and Turku University Hospital, Turku, Finland.
Am J Cardiol ; 222: 78-86, 2024 07 01.
Article em En | MEDLINE | ID: mdl-38723856
ABSTRACT
The underlying mechanisms leading to the development of mitral regurgitation (MR) after right ventricular (RV) pacemaker (PM) implantation and its prognostic value have yet to be fully understood. The purpose of this study was to evaluate the prevalence and clinical variables associated with the development of MR after RV pacing and its association with outcomes. A total of 451 patients (mean age 69 ± 15 years, 61% male) who underwent de novo RV PM implantation were included. The development of significant MR, defined as ≥moderate from mild or none/trace at baseline, occurred in 131 (29%) patients at a median of 2.4 years (interquartile range 1.0 to 3.8 years) after PM implantation. Multivariate logistic regression analysis demonstrated that implantation of a single-chamber PM, left ventricular end-systolic volume index, and the presence of mild MR (vs no MR) at baseline were independently associated with the development of significant MR post-implant. Cardiac events, defined as the composite of all-cause mortality or heart failure hospitalization, occurred in 143 patients (31.7%) during a median follow-up of 5.4 years (interquartile range 3.0 to 8.1 years). Multivariate Cox regression analysis demonstrated that the development of significant MR was independently related to the occurrence of cardiac events. In conclusion, the development of significant MR after PM implantation is seen in about one-third of recipients and is independently associated with adverse cardiac events.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Marca-Passo Artificial / Ventrículos do Coração / Insuficiência da Valva Mitral Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Cardiol Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Marca-Passo Artificial / Ventrículos do Coração / Insuficiência da Valva Mitral Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Cardiol Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos