A 3'-pre-tRNA-derived small RNA tRF-1-Ser regulated by 25(OH)D promotes proliferation and stemness by inhibiting the function of MBNL1 in breast cancer.

Wan, Xinyu; Shi, Wenjie; Ma, Lingjun; Wang, Lexin; Zheng, Ran; He, Jinzhi; Wang, Ye; Li, Xuan; Zha, Xiaoming; Wang, Jue; Xu, Lu

Wan, Xinyu; Shi, Wenjie; Ma, Lingjun; Wang, Lexin; Zheng, Ran; He, Jinzhi; Wang, Ye; Li, Xuan; Zha, Xiaoming; Wang, Jue; Xu, Lu.

Afiliação

Wan X; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Shi W; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ma L; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang L; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zheng R; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
He J; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang Y; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Li X; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zha X; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang J; Department of Breast Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xu L; Department of Nutrition, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Clin Transl Med ; 14(5): e1681, 2024 May.

Article em En | MEDLINE | ID: mdl-38725048

Assuntos

Neoplasias da Mama; Proliferação de Células; Proteínas de Ligação a RNA; Vitamina D; Humanos; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Feminino; Vitamina D/metabolismo; Vitamina D/análogos & derivados; Vitamina D/farmacologia; Proteínas de Ligação a RNA/metabolismo; Proteínas de Ligação a RNA/genética; Proliferação de Células/genética; Camundongos; Animais

Palavras-chave

25hydroxyvitamin D; MBNL1; RNA splicing; nutrition; tRNAderived fragments

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Neoplasias da Mama / Proteínas de Ligação a RNA / Proliferação de Células Limite: Animals / Female / Humans Idioma: En Revista: Clin Transl Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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