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Sex Disparity in the Association of Metabolic Syndrome with Cognitive Impairment.
Chang, Yi-Min; Lee, Chia-Lin; Wang, Jun-Sing.
Afiliação
  • Chang YM; Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
  • Lee CL; Intelligent Data Mining Laboratory, Department of Medical Research, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
  • Wang JS; Department of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
J Clin Med ; 13(9)2024 Apr 27.
Article em En | MEDLINE | ID: mdl-38731099
ABSTRACT
Background/

Objectives:

Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank.

Methods:

We determined the associations of MS and its five components with cognitive impairment (mini-mental state examination, MMSE < 24) and the five domains of MMSE using logistic regression analyses.

Results:

A total of 7399 men and 11,546 women were included, and MS was significantly associated with cognitive impairment only in women (adjusted OR 1.48, 95% CI 1.29-1.71, p = 0.001) (p for interaction 0.005). In women, the association with MS was significant in orientation (adjusted OR 1.21, 95% CI 1.07-1.37, p = 0.003), memory (adjusted OR 1.12, 95% CI 1.01-1.25, p = 0.034) and design copying (adjusted OR 1.41, 95% CI 1.23-1.62, p = 0.001) (p value for interaction 0.039, 0.023, and 0.093, respectively). Among the components of MS, a large waist circumference (adjusted OR 1.25, 95% CI 1.08-1.46, p = 0.003), high fasting glucose (adjusted OR 1.16, 95% CI 1.00-1.34, p = 0.046), and low HDL cholesterol (adjusted OR 1.16, 95% CI 1.00-1.34, p = 0.049) were significantly associated with cognitive impairment in women.

Conclusions:

Our findings suggest that sex has a significant influence on the association between MS and cognitive dysfunction, especially in orientation and memory.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan