[Pathogenic Mechanisms of Diabetic Neuropathy].
Brain Nerve
; 76(5): 671-680, 2024 May.
Article
em Ja
| MEDLINE
| ID: mdl-38741511
ABSTRACT
Diabetes stands as the predominant cause of peripheral neuropathy, and diabetic neuropathy (DN) is an early-onset and most frequent complication of diabetes. Distal symmetric polyneuropathy is the major form of DN; however, various patterns of nerve injury can manifest. Growing evidence suggests that hyperglycemia-related metabolic disorders in neurons, Schwann cells, and vascular endothelial cells play a major role in the development and progression of DN; however, its pathogenesis and development of disease-modifying therapies warrant further investigation. Herein, recent studies regarding the possible pathogenic factors of DN (polyol and other collateral glycolysis pathways, glycation, oxidative stress, Rho/Rho kinase signaling pathways, etc.) and therapeutic strategies targeting these factors are introduced.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Neuropatias Diabéticas
Limite:
Animals
/
Humans
Idioma:
Ja
Revista:
Brain Nerve
Assunto da revista:
CEREBRO
/
NEUROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Japão