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Neural basis for pheromone signal transduction in mice.
Murata, Ken; Itakura, Takumi; Touhara, Kazushige.
Afiliação
  • Murata K; Laboratory of Biological Chemistry, Graduate School of Agricultural and Life Sciences, Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
  • Itakura T; Laboratory of Biological Chemistry, Graduate School of Agricultural and Life Sciences, Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
  • Touhara K; Division of Biology and Biological Engineering, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA, United States.
Front Neural Circuits ; 18: 1409994, 2024.
Article em En | MEDLINE | ID: mdl-38742089
ABSTRACT
Pheromones are specialized chemical messengers used for inter-individual communication within the same species, playing crucial roles in modulating behaviors and physiological states. The detection mechanisms of these signals at the peripheral organ and their transduction to the brain have been unclear. However, recent identification of pheromone molecules, their corresponding receptors, and advancements in neuroscientific technology have started to elucidate these processes. In mammals, the detection and interpretation of pheromone signals are primarily attributed to the vomeronasal system, which is a specialized olfactory apparatus predominantly dedicated to decoding socio-chemical cues. In this mini-review, we aim to delineate the vomeronasal signal transduction pathway initiated by specific vomeronasal receptor-ligand interactions in mice. First, we catalog the previously identified pheromone ligands and their corresponding receptor pairs, providing a foundational understanding of the specificity inherent in pheromonal communication. Subsequently, we examine the neural circuits involved in processing each pheromone signal. We focus on the anatomical pathways, the sexually dimorphic and physiological state-dependent aspects of signal transduction, and the neural coding strategies underlying behavioral responses to pheromonal cues. These insights provide further critical questions regarding the development of innate circuit formation and plasticity within these circuits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Feromônios / Transdução de Sinais / Órgão Vomeronasal Limite: Animals Idioma: En Revista: Front Neural Circuits Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Feromônios / Transdução de Sinais / Órgão Vomeronasal Limite: Animals Idioma: En Revista: Front Neural Circuits Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão País de publicação: Suíça