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Activity of propyl-propane-thiosulfinate and propyl-propane-thiosulfonate against carbapenem-resistant Gram-negative bacteria.
Sorlózano-Puerto, Antonio; Cerezo-Collado, Laura; Roca-Lagrilliere, Elvira; Baños-Arjona, Alberto; Gutiérrez-Fernández, José.
Afiliação
  • Sorlózano-Puerto A; Department of Microbiology, School of Medicine, University of Granada-ibs, Granada, Spain.
  • Cerezo-Collado L; Department of Microbiology, School of Medicine, University of Granada-ibs, Granada, Spain.
  • Roca-Lagrilliere E; Department of Microbiology, School of Medicine, University of Granada-ibs, Granada, Spain.
  • Baños-Arjona A; DMC Research Center, Camino de Jayena, Alhendín, Spain.
  • Gutiérrez-Fernández J; Department of Microbiology, School of Medicine, University of Granada-ibs, Granada, Spain.
APMIS ; 132(8): 581-593, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38757239
ABSTRACT
Organosulfur compounds derived from plants of the Allium genus, such as propyl-propane-thiosulfinate (PTS) and propyl-propane-thiosulfonate (PTSO), have been proposed as an alternative in antibiotic resistance. The aim of this study was to compare the activity of these substances with other antibiotics against clinical isolates of carbapenem-resistant (CAR-R) and carbapenem-susceptible (CAR-S) Gram-negative bacteria. A total of 126 clinical isolates of CAR-R and 155 CAR-S bacteria were selected, including Enterobacterales, A. baumannii and P. aeruginosa. The antibiotic susceptibility of all isolates was assessed using the microdilution and Kirby-Bauer methods for PTS, PTSO, amoxicillin/clavulanate, piperacillin/tazobactam, cefotaxime, ceftazidime, cefepime, imipenem, ciprofloxacin, and amikacin. Both PTS and PTSO demonstrated in vitro bactericidal activity against CAR-R Enterobacteriaceae and A. baumannii, with no significant difference in activity compared to their response against CAR-S isolates. However, both compounds were less active against P. aeruginosa than against any of the other bacteria, regardless of their resistance to carbapenems. In all cases, the minimum inhibitory concentration values of PTSO were significantly lower than those of PTS. These findings offer valuable information about the potential antibacterial use of these substances, particularly against infections that currently have limited therapeutic options.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Sensibilidade Microbiana / Carbapenêmicos / Bactérias Gram-Negativas / Antibacterianos Limite: Humans Idioma: En Revista: APMIS Assunto da revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Sensibilidade Microbiana / Carbapenêmicos / Bactérias Gram-Negativas / Antibacterianos Limite: Humans Idioma: En Revista: APMIS Assunto da revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Dinamarca