Fluorescent Probes for Disease Diagnosis.
Chem Rev
; 124(11): 7106-7164, 2024 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-38760012
ABSTRACT
The identification and detection of disease-related biomarkers is essential for early clinical diagnosis, evaluating disease progression, and for the development of therapeutics. Possessing the advantages of high sensitivity and selectivity, fluorescent probes have become effective tools for monitoring disease-related active molecules at the cellular level and in vivo. In this review, we describe current fluorescent probes designed for the detection and quantification of key bioactive molecules associated with common diseases, such as organ damage, inflammation, cancers, cardiovascular diseases, and brain disorders. We emphasize the strategies behind the design of fluorescent probes capable of disease biomarker detection and diagnosis and cover some aspects of combined diagnostic/therapeutic strategies based on regulating disease-related molecules. This review concludes with a discussion of the challenges and outlook for fluorescent probes, highlighting future avenues of research that should enable these probes to achieve accurate detection and identification of disease-related biomarkers for biomedical research and clinical applications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Corantes Fluorescentes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Rev
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos