The F-actin bundler SWAP-70 promotes tumor metastasis.
Life Sci Alliance
; 7(8)2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38760173
ABSTRACT
Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Antígenos de Histocompatibilidade Menor
/
Actinas
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Fatores de Troca do Nucleotídeo Guanina
/
Proteínas de Ligação a DNA
/
Neoplasias Pulmonares
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Proteínas dos Microfilamentos
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Metástase Neoplásica
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Life Sci Alliance
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha
País de publicação:
Estados Unidos