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Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus.
Kong, Lin; Zhang, Rongyuan; Gong, Junyi; Wang, Huan; Zhai, Lingyu; Dang, Dongfeng; Liu, Qian; Zhao, Zheng; Tang, Ben Zhong.
Afiliação
  • Kong L; College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China.
  • Zhang R; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHKSZ), Shenzhen, Guangdong 518172, China. zhaozheng@cuhk.edu.cn.
  • Gong J; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHKSZ), Shenzhen, Guangdong 518172, China. zhaozheng@cuhk.edu.cn.
  • Wang H; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHKSZ), Shenzhen, Guangdong 518172, China. zhaozheng@cuhk.edu.cn.
  • Zhai L; College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China.
  • Dang D; College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, P. R. China.
  • Liu Q; School of Science, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • Zhao Z; Department of Urology, Tianjin First Central Hospital, Tianjin 300192, China.
  • Tang BZ; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHKSZ), Shenzhen, Guangdong 518172, China. zhaozheng@cuhk.edu.cn.
Chem Commun (Camb) ; 60(46): 5960-5963, 2024 Jun 04.
Article em En | MEDLINE | ID: mdl-38767007
ABSTRACT
A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Sensibilidade Microbiana / Fármacos Fotossensibilizantes / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Animals Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Sensibilidade Microbiana / Fármacos Fotossensibilizantes / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Animals Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article