Pregnancy in women with nephrotic-range proteinuria: A retrospective cohort study.
Obstet Med
; 17(2): 96-100, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38784182
ABSTRACT
Background:
Obstetric and kidney outcomes following detection of nephrotic-range proteinuria in early pregnancy have not been well described.Methods:
A retrospective cohort study of chronic kidney disease (CKD) in pregnancy between 2008 and 2018. Outcomes in those with nephrotic-range proteinuria before 20 weeks' gestation were compared to those without nephrotic-range proteinuria.Results:
The study included 37 women with nephrotic-range proteinuria and 62 women without. Pre-pregnancy estimated glomerular filtration rate (eGFR) was similar. Nephrotic-range proteinuria was associated with higher rates of preterm (odds ratio [OR] 1.77, 95% confidence interval [CI] 1.07-2.92) and early preterm delivery (OR 2.63, 95% CI 1.12-6.2), and with a requirement for renal replacement therapy at 3 years post-partum (OR 10.72, 95% CI 2.58-44.47). Tubulointerstitial scarring on kidney biopsy was associated with early preterm delivery and progression to advanced CKD, independent of pre-pregnancy eGFR.Conclusion:
Compared to CKD without nephrotic-range proteinuria, nephrotic-range proteinuria early in pregnancy is associated with higher rates of pre-term delivery and progression to advanced CKD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Obstet Med
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido