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Melatonin improves nitric oxide bioavailability in isoproterenol induced myocardial injury.
Santos, Ramison; Turck, Patrick; de Mello Palma, Victor; Visioli, Fernanda; Ortiz, Vanessa Duarte; Proença, Isabel Cristina Teixeira; Fernandes, Tânia Regina G; Fernandes, Elissa; Tasca, Silvio; Carraro, Cristina Campos; Belló-Klein, Adriane; da Rosa Araujo, Alex Sander; Khaper, Neelam; de Castro, Alexandre Luz.
Afiliação
  • Santos R; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Turck P; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • de Mello Palma V; Faculdade de Odontologia. Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2492 - Santa Cecília, CEP: 90035-004, Porto Alegre, RS, Brazil.
  • Visioli F; Faculdade de Odontologia. Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2492 - Santa Cecília, CEP: 90035-004, Porto Alegre, RS, Brazil.
  • Ortiz VD; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Proença ICT; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Fernandes TRG; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Fernandes E; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Tasca S; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Carraro CC; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Belló-Klein A; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • da Rosa Araujo AS; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil.
  • Khaper N; Northern Ontario School of Medicine University, 955 Oliver Road, Thunder Bay, ON, Canada.
  • de Castro AL; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street, 2600 - Santa Cecília, CEP: 90035-003, Porto Alegre, RS, Brazil. Electronic address: alexluzca
Mol Cell Endocrinol ; 591: 112279, 2024 Sep 15.
Article em En | MEDLINE | ID: mdl-38797355
ABSTRACT
Isoproterenol administration is associated with cardiac inflammation and decreased NO availability. Melatonin has been reported to have cardioprotective effect. The aim of this study was to investigate the effect of melatonin on NO bioavailability and inflammation in myocardial injury induced by isoproterenol. Isoproterenol was administrated in male Wistar rats for 7 days to induce cardiac injury. The animals were divided into 3 groups Control, Isoproterenol, Isoproterenol + Melatonin. Animals received melatonin for 7 days. Echocardiographic analysis was performed and the hearts were collected for molecular analysis. Animals that received isoproterenol demonstrated a reduction in left ventricle systolic and diastolic diameter, indicating the presence of concentric hypertrophy. Melatonin was able to attenuate this alteration. Melatonin also improved NO bioavailability and decreased NF-κß, TNFα and IL-1ß expression. In conclusion, melatonin exhibited a cardioprotective effect which was associated with improving NO bioavailability and decreasing the pro-inflammatory proteins.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disponibilidade Biológica / Ratos Wistar / Isoproterenol / Melatonina / Óxido Nítrico Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: IE / IRELAND / IRLANDA
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disponibilidade Biológica / Ratos Wistar / Isoproterenol / Melatonina / Óxido Nítrico Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: IE / IRELAND / IRLANDA