Afatinib-induced toxic epidermal necrolysis: A case report with a literature review.

Belancic, Andrej; Hlaca, Nika; Peternel, Sandra; Golcic, Marin; Prpic-Massari, Larisa; Vlahovic-Palcevski, Vera

Belancic, Andrej; Hlaca, Nika; Peternel, Sandra; Golcic, Marin; Prpic-Massari, Larisa; Vlahovic-Palcevski, Vera.

Afiliação

Belancic A; Department of Clinical Pharmacology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Hlaca N; Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Peternel S; Department of Dermatovenerology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Golcic M; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Prpic-Massari L; Department of Dermatovenerology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Vlahovic-Palcevski V; Department of Dermatovenerology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Br J Clin Pharmacol ; 90(8): 2030-2033, 2024 Aug.

Article em En | MEDLINE | ID: mdl-38803188

ABSTRACT

ABSTRACT

We present a 70-year-old female patient diagnosed with epidermal growth factor receptor-mutated metastatic non-small cell lung cancer (T4N2M1a), who developed afatinib-induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens-Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib-induced TEN successfully treated with cyclosporine.

Assuntos

Afatinib; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Síndrome de Stevens-Johnson; Humanos; Afatinib/efeitos adversos; Afatinib/uso terapêutico; Feminino; Idoso; Síndrome de Stevens-Johnson/etiologia; Síndrome de Stevens-Johnson/tratamento farmacológico; Neoplasias Pulmonares/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Quinazolinas/efeitos adversos; Quinazolinas/uso terapêutico; Antineoplásicos/efeitos adversos; Ciclosporina/efeitos adversos; Ciclosporina/uso terapêutico; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/genética

Palavras-chave

afatinib; pharmacovigilance; serious adverse drug reaction; toxic epidermal necrolysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Stevens-Johnson / Carcinoma Pulmonar de Células não Pequenas / Afatinib / Neoplasias Pulmonares Limite: Aged / Female / Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Croácia País de publicação: Reino Unido

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