The association between testosterone and serum soluble klotho in the females: evidence from the NHANES database.
Front Endocrinol (Lausanne)
; 15: 1335611, 2024.
Article
em En
| MEDLINE
| ID: mdl-38818507
ABSTRACT
Objective:
This research aimed to elucidate the relationship between testosterone levels and serum soluble klotho (S-klotho) concentrations in females aged 40-79 years using the National Health and Nutrition Examination Survey (NHANES) dataset.Design:
Associations between testosterone and S-klotho were assessed through multivariable linear regression methodologies, spanning nonadjusted, minimally adjusted, and fully adjusted models. Settings The investigation was conducted as a cross-sectional analysis utilizing the NHANES database.Participants:
From 20,146 NHANES participants between 2013 and 2016, 2,444 females met the stipulated inclusion and exclusion criteria.Results:
Free androgen index (FAI) showcased a negative correlation with S-klotho levels across all regression models (nonadjusted ß -7.08, 95% CI -13.39- -0.76; minimally adjusted ß -9.73, 95% CI -16.6- -2.84; fully adjusted ß -7.63, 95% CI -14.75-0.51). Conversely, total testosterone did not exhibit significant associations with S-klotho across the models. In the nonadjusted model, estradiol was positively associated with S-klotho concentrations (ß 0.14, 95% CI 0.05-0.23), but this significance was not retained in subsequent regression models.Conclusion:
Findings suggest that in U.S. females aged 40-79 years, FAI negatively correlates with S-klotho concentrations, while there is the lack of significant associations for total testosterone and estradiol.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Inquéritos Nutricionais
/
Proteínas Klotho
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China