Your browser doesn't support javascript.
loading
Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss.
Froemming, Mitchell N; Khosla, Sundeep; Farr, Joshua N.
Afiliação
  • Froemming MN; Division of Endocrinology, Rochester, MN, 55905, USA.
  • Khosla S; Robert and Arlene Kogod Center On Aging, Rochester, MN, 55905, USA.
  • Farr JN; Division of Endocrinology, Rochester, MN, 55905, USA.
Curr Osteoporos Rep ; 22(4): 378-386, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38829487
ABSTRACT
PURPOSE OF REVIEW Beyond aging, senescent cells accumulate during multiple pathological conditions, including chemotherapy, radiation, glucocorticoids, obesity, and diabetes, even earlier in life. Therefore, cellular senescence represents a unifying pathogenic mechanism driving skeletal and metabolic disorders. However, whether senescent bone marrow adipocytes (BMAds) are causal in mediating skeletal dysfunction has only recently been evaluated. RECENT

FINDINGS:

Despite evidence of BMAd senescence following glucocorticoid therapy, additional evidence for BMAd senescence in other conditions has thus far been limited. Because the study of BMAds presents unique challenges making these cells difficult to isolate and image, here we review issues and approaches to overcome such challenges, and present advancements in isolation and histological techniques that may help with the future study of senescent BMAds. Further insights into the roles of BMAd senescence in the pathogenesis of skeletal dysfunction may have important basic science and clinical implications for human physiology and disease.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular / Adipócitos Limite: Animals / Humans Idioma: En Revista: Curr Osteoporos Rep Assunto da revista: ORTOPEDIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular / Adipócitos Limite: Animals / Humans Idioma: En Revista: Curr Osteoporos Rep Assunto da revista: ORTOPEDIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos