Waist-to-height ratio and body fat percentage as risk factors for ischemic cardiovascular disease: a prospective cohort study from UK Biobank.
Am J Clin Nutr
; 119(6): 1386-1396, 2024 06.
Article
em En
| MEDLINE
| ID: mdl-38839194
ABSTRACT
BACKGROUND:
The independent effect of waist-to-height ratio (WHtR) and body fat percentage (BF%) on ischemic cardiovascular disease (CVD) remains uncertain.OBJECTIVES:
This study aimed to investigate the independent associations of WHtR and BF% with ischemic CVD.METHODS:
This prospective cohort study used data from the UK Biobank. BF% was calculated as fat mass divided by body weight, measured by bioimpedance. Cox models estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for overall and sex-specific associations of BF% and WHtR with risks of ischemic CVD and its main subtypes [myocardial infarction (MI) and ischemic stroke (IS)], adjusted for a range of potential confounders, including mutual adjustment for BF% and WHtR.RESULTS:
In total, 468,333 participants without existing CVD were included in the analysis. During 12 y of follow-up, 20,151 ischemic CVD events, 13,604 MIs, and 6681 ISs were recorded. WHtR was linearly associated with ischemic CVD, MI, and IS, with an HR per 5% increase of 1.23 (95% CI 1.20, 1.25), 1.24 (95% CI 1.21, 1.27), and 1.22 (95% CI 1.18, 1.26), respectively, independent of BF%. A stronger association between WHtR and MI was seen in females than in males. The association of BF% with these outcomes was substantially attenuated in both sexes after adjustment for WHtR. For example, in females, the HR (highest compared with lowest fifth) was reduced from 1.94 (95% CI 1.76, 2.15) to 1.04 (95% CI 0.90, 1.01) for ischemic CVD, from 2.04 (95% CI 1.79, 2.32) to 0.97 (95% CI 0.81, 1.16) for MI, and from 1.81 (95% CI 1.54, 2.13) to 1.07 (95% CI 0.85, 1.33) for IS.CONCLUSIONS:
WHtR, when used as a proxy measure for central obesity, is linearly associated with ischemic CVD in both sexes, which is independent of BF%. In contrast, the relationship of BF% with these health outcomes is predominantly driven by its correlation with WHtR.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
/
Bancos de Espécimes Biológicos
/
Razão Cintura-Estatura
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos