Elevated proinflammatory cytokines in response to mechanical stimulus are associated with reduced knee loading 2 years after anterior cruciate ligament reconstruction.
Clin Biomech (Bristol, Avon)
; 116: 106286, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38850881
ABSTRACT
BACKGROUND:
The aim of this study was to test the hypothesis that proinflammatory cytokines correlate with knee loading mechanics during gait following a mechanical walking stimulus in subjects 2 years after anterior cruciate ligament reconstruction. Elevated systemic levels of proinflammatory cytokines can be sustained for years after injury. Considering roughly 50% of these patients progress to Osteoarthritis 10-15 years after injury, a better understanding of the role of proinflammatory cytokines such as tumor necrosis factor-α and Interleukin-1ß on Osteoarthritis risk is needed.METHODS:
Serum proinflammatory cytokines concentrations were measured in 21 subjects 2 years after unilateral ACLR from blood drawn at rest and 3.5 h after 30 min of walking. An optoelectronic system and a force plate measured subjects' knee kinetics. Correlations were tested between inflammatory marker response and knee extension and knee adduction moments.FINDINGS:
Changes in proinflammatory cytokines due to mechanical stimulus were correlated (R = 0.86) and showed substantial variation between subjects in both cytokines at 3.5 h post-walk. Knee loading correlated with 3.5-h changes in tumor necrosis factor-α concentration (Knee extension moment R = -0.5, Knee adduction moment R = -0.5) and Interleukin-1ß concentration (Knee extension moment R = -0.44). However, no significant changes in concentrations were observed in tumor necrosis factor-α and Interleukin-1ß when comparing baseline and post walking stimulus conditions.INTERPRETATION:
The significant associations between changes in serum proinflammatory markers following a mechanical stimulus and gait metrics in subjects at risk for developing Osteoarthritis underscore the importance of investigating the interaction between biomarkers and biomechanical factors in Osteoarthritis development.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Reconstrução do Ligamento Cruzado Anterior
/
Articulação do Joelho
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Biomech (Bristol, Avon)
Assunto da revista:
ENGENHARIA BIOMEDICA
/
FISIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido