Associations between paediatric obesity, chemical mixtures and environmental factors, in a national cross-sectional study of Canadian children.
Pediatr Obes
; 19(8): e13117, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38872449
ABSTRACT
BACKGROUND:
Whilst single chemical exposures are suspected to be obesogenic, the combined role of chemical mixtures in paediatric obesity is not well understood.OBJECTIVES:
We aimed to evaluate the potential associations between chemical mixtures and obesity in a population-based sample of Canadian children.METHODS:
We ascertained biomonitoring and health data for children aged 3-11 from the cross-sectional Canadian Health Measures Survey from 2007 to 2019. Several chemicals of interest were measured in blood or urine and paediatric obesity was defined based on measured anthropometrics. Using quantile-based G computational analysis, we quantified the effects of three chemical mixtures selected a priori. Models were adjusted for sociodemographic and environmental factors identified through a directed acyclic graph. Results are presented through adjusted relative risks (RR) with 95% confidence intervals (95% CI).RESULTS:
We included 9147 children. Of these, 24.1% were overweight or obese. Exposure to the mixture of bisphenol A, acrylamide, glycidamide, metals, parabens and arsenic increased the risk of childhood overweight or obesity by 45% (95% CI 1.09, 1.93), obesity by 109% (95% CI 1.27, 3.42) and central obesity by 82% (95% CI 1.30, 2.56).CONCLUSIONS:
Our findings support the role of early childhood chemical exposures in paediatric obesity and the potential combined effects of chemicals.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exposição Ambiental
/
Obesidade Infantil
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Pediatr Obes
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá