The Roles of Endogenous Opioids in Placebo and Nocebo Effects: From Pain to Performance to Prozac.
Adv Neurobiol
; 35: 183-220, 2024.
Article
em En
| MEDLINE
| ID: mdl-38874724
ABSTRACT
Placebo and nocebo effects have been well documented for nearly two centuries. However, research has only relatively recently begun to explicate the neurobiological underpinnings of these phenomena. Similarly, research on the broader social implications of placebo/nocebo effects, especially within healthcare delivery settings, is in a nascent stage. Biological and psychosocial outcomes of placebo/nocebo effects are of equal relevance. A common pathway for such outcomes is the endogenous opioid system. This chapter describes the history of placebo/nocebo in medicine; delineates the current state of the literature related to placebo/nocebo in relation to pain modulation; summarizes research findings related to human performance in sports and exercise; discusses the implications of placebo/nocebo effects among diverse patient populations; and describes placebo/nocebo influences in research related to psychopharmacology, including the relevance of endogenous opioids to new lines of research on antidepressant pharmacotherapies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Efeito Placebo
/
Efeito Nocebo
Limite:
Humans
Idioma:
En
Revista:
Adv Neurobiol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos