Your browser doesn't support javascript.
loading
Application of a generic PBK model for beef cattle: Tissue/fluid correlations of paracetamol and NSAIDs.
Lautz, L S; Melchers, T C; Noorlander, A; Stoopen, G; Arrizabalaga-Larrañaga, A.
Afiliação
  • Lautz LS; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands.
  • Melchers TC; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands.
  • Noorlander A; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands.
  • Stoopen G; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands.
  • Arrizabalaga-Larrañaga A; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherlands. Electronic address: ane.arrizabalagalarranaga@wur.nl.
Food Chem Toxicol ; 190: 114812, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38879144
ABSTRACT
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and paracetamol can be administered off-label to cattle. Since the use of these veterinary medicines in cattle may pose a public health risk after meat consumption, it is important to translate measured concentrations in urine and tissues into concentrations in meat for human consumption. A generic physiologically-based kinetic (PBK) model for cattle can enable this translation. In this work, a beef cattle PBK model was applied to calculate the relationships between concentrations in different bovine tissues and those were compared to measured concentrations in different matrices. Sixty-seven kidney samples, the corresponding urine and meat samples, and available 19 serum samples were analysed. Overall, 70% of the PBK model predictions are within a 2-fold factor and relationships for kidney/meat, urine/meat, and plasma/meat ratios were established. The conversions of measured kidney concentrations into meat concentrations were mostly within a factor two, while those based on plasma and urine were underpredicted. Based on these ratios, plasma and urine could be used as an appropriate surrogate matrix for a fast, simple in vivo sample screening test under field conditions, such as in local farms and slaughterhouses, to predict a maximum residue level exceedance in meat, reducing the number of test samples.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anti-Inflamatórios não Esteroides / Acetaminofen Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anti-Inflamatórios não Esteroides / Acetaminofen Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido