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Postmenopausal Pregnancy Via Oocyte Donor and Suspected Focal Placenta Accreta: A Case Report.
Hajjar, Rima; Cooper, Saladin A; Elumalai, Nila; Hussain, Hussain; Patrizio, Rebecca; Sinno, Abdulrahman; Ahmad, Anis; Marbin, Staci; Ruiz-Cordero, Roberto; Paidas, Michael J; Jayakumar, Arumugam R.
Afiliação
  • Hajjar R; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
  • Cooper SA; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
  • Elumalai N; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
  • Hussain H; Department of Internal Medicine, Hospital Corporation of America (HCA) Florida Kendall Hospital, Miami, USA.
  • Patrizio R; Department of Biology, New York University (NYU) College of Arts and Science, New York, USA.
  • Sinno A; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
  • Ahmad A; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, USA.
  • Marbin S; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
  • Ruiz-Cordero R; Department of Pathology and Laboratory Medicine, University of Miami, Miami, USA.
  • Paidas MJ; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
  • Jayakumar AR; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, USA.
Cureus ; 16(6): e62332, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38882221
ABSTRACT
Advances in assisted reproductive technologies have enabled postmenopausal women to achieve pregnancy beyond their reproductive lifespan. Although rare, these pregnancies are challenging and require a multidisciplinary approach due to the higher prevalence of medical comorbidities in this population. The placenta accreta spectrum is characterized by an abnormal invasion of chorionic villi into the myometrium. Risk factors associated with the placenta accreta spectrum include prior uterine surgeries, advanced maternal age, multiparity, in vitro fertilization, and placenta previa. We present a case of a 59-year-old postmenopausal woman with chronic hypertension, stage II chronic kidney injury, and superimposed pre-eclampsia who underwent cesarean delivery complicated by suspected focal placenta accreta. Histopathological examination revealed significant deviations from normative placental architecture, emphasizing the invasion of the villi. Further, congested blood vessels and the presence of inflammatory cells, along with heightened collagen deposition, suggest an underlying pathological process affecting placental health. These findings underscore a perturbation of placental homeostasis, emphasizing the necessity for further investigation into the mechanisms contributing to placental pathology in postmenopausal pregnancies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cureus Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cureus Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos