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Cefiderocol utilization in lung transplant recipients at a single center.
Persaud, Purnadeo N; Xhemali, Xhilda; Neuhaus, Kristen; Budev, Marie; Lum, Jessica.
Afiliação
  • Persaud PN; Cleveland Clinic Foundation, Department of Internal Medicine, Cleveland, Ohio, USA.
  • Xhemali X; Clevleand Clinic Foundation, Department of Pharmacy, Cleveland, Ohio, USA.
  • Neuhaus K; Clevleand Clinic Foundation, Department of Pharmacy, Cleveland, Ohio, USA.
  • Budev M; Cleveland Clinic Foundation, Department of Pulmonary Medicine, Cleveland, Ohio, USA.
  • Lum J; Cleveland Clinic Foundation, Department of Infectious Disesaes, Cleveland, Ohio, USA.
Transpl Infect Dis ; 26(4): e14319, 2024 Aug.
Article em It | MEDLINE | ID: mdl-38884771
ABSTRACT

BACKGROUND:

Multidrug-resistant organisms are increasing and are a significant cause of mortality among lung transplant recipients (LTRs). To assist with this issue, novel pharmacotherapies are being developed. This study describes the utilization of a novel antibiotic, cefiderocol (FDC), in LTRs where limited data exists in the current literature. We primarily assessed the clinical indications, duration of therapy, resistance, and adverse effects.

METHODS:

Conducted as a single-center retrospective review, this study included adult LTRs who received FDC for at least 24 h. Data, extracted from electronic medical records, encompassed patient demographics, transplant history, antimicrobial dosing, adverse effects, bacterial cultures, and outcomes. The research protocol received institutional review board approval.

RESULTS:

FDC exhibited effectiveness against multidrug-resistant Pseudomonas aeruginosa, with 26% 30-day mortality and microbiological clearance observed in nine out of 13 cases. Notably, FDC was used in diverse clinical settings, including for prophylaxis, empiric, and targeted treatment.

CONCLUSION:

Further studies are needed to evaluate optimal clinical indications for FDC use in LTRs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Cefalosporinas / Transplante de Pulmão / Farmacorresistência Bacteriana Múltipla / Transplantados / Cefiderocol / Antibacterianos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: It Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Cefalosporinas / Transplante de Pulmão / Farmacorresistência Bacteriana Múltipla / Transplantados / Cefiderocol / Antibacterianos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: It Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos