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Nanotechnology in medicine revolutionizing drug delivery for cancer and viral infection treatments.
Karahmet Sher, Emina; Alebic, Mirna; Markovic Boras, Marijana; Boskailo, Emina; Karahmet Farhat, Esma; Karahmet, Alma; Pavlovic, Bojan; Sher, Farooq; Lekic, Lana.
Afiliação
  • Karahmet Sher E; School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom. Electronic address: Emina.Sher@isest.org.
  • Alebic M; Department of Pharmacy, University Hospital Centre Zagreb, Zagreb 10000, Croatia.
  • Markovic Boras M; Department of Laboratory Diagnostic, University Clinical Hospital Mostar, Mostar 88000, Bosnia and Herzegovina; International Society of Engineering Science and Technology, Nottingham, United Kingdom.
  • Boskailo E; International Society of Engineering Science and Technology, Nottingham, United Kingdom.
  • Karahmet Farhat E; International Society of Engineering Science and Technology, Nottingham, United Kingdom; Department of Food and Nutrition, Faculty of Food Technology, Juraj Strossmayer University of Osijek, Osijek 31000, Croatia.
  • Karahmet A; International Society of Engineering Science and Technology, Nottingham, United Kingdom.
  • Pavlovic B; Faculty of Physical Education and Sports, University of East Sarajevo, Lukavica, Republika Srpska 75327, Bosnia and Herzegovina.
  • Sher F; School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom. Electronic address: Farooq.Sher@ntu.ac.uk.
  • Lekic L; Faculty of Health Studies, University of Sarajevo, Sarajevo 71000, Bosnia and Herzegovina.
Int J Pharm ; 660: 124345, 2024 Jul 20.
Article em En | MEDLINE | ID: mdl-38885775
ABSTRACT
Advancements in nanotechnology were vastly applied in medicine and pharmacy, especially in the field of nano-delivery systems. It took a long time for these systems to ensure precise delivery of very delicate molecules, such as RNA, to cells at concentrations that yield remarkable efficiency, with success rates reaching 95.0% and 94.5%. These days, there are several advantages of using nanotechnological solutions in the prevention and treatment of cancer and viral infections. Its interventions improve treatment outcomes both due to increased effectiveness of the drug at target location and by reducing adverse reactions, thereby increasing patient adherence to the therapy. Based on the current knowledge an updated review was made, and perspective, opportunities and challenges in nanomedicine were discussed. The methods employed include comprehensive examination of existing literature and studies on nanoparticles and nano-delivery systems including both in vitro tests performed on cell cultures and in vivo assessments carried out on appropriate animal models, with a specific emphasis on their applications in oncology and virology. This brings together various aspects including both structure and formation as well as its association with characteristic behaviour in organisms, providing a novel perspective. Furthermore, the practical application of these systems in medicine and pharmacy with a focus on viral diseases and malignancies was explored. This review can serve as a valuable guide for fellow researchers, helping them navigate the abundance of findings in this field. The results indicate that applications of nanotechnological solutions for the delivery of medicinal products improving therapeutic outcomes will continue to expand.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viroses / Sistemas de Liberação de Medicamentos / Nanotecnologia / Nanomedicina / Neoplasias Limite: Animals / Humans Idioma: En Revista: Int J Pharm Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viroses / Sistemas de Liberação de Medicamentos / Nanotecnologia / Nanomedicina / Neoplasias Limite: Animals / Humans Idioma: En Revista: Int J Pharm Ano de publicação: 2024 Tipo de documento: Article
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